The angiogenic properties of micron-sized m−BG and nano-sized n−BG bioactive glass BG filled polyD,Llactide PDLLA composites were investigated. On the basis of cell culture work investigating the secretion of vascular endothelial growth factor VEGF by human fibroblasts in contact with composite films 0,5,10,20wt, porous 3D composite scaffolds, optimised with respect to the BG filler content capable of inducing angiogenic response, were produced. The in vivo vascularisation of the scaffolds was studied in a rat animal model and quantified using stereological analyses. The prepared scaffolds had high porosities 81–93, permeability (k = 5.4–8.6 × 10⁻⁹ m²) and compressive strength values 0.4–1.6MPa all in the range of trabecular bone. On composite films containing 20 wt % m-BG or n-BG, human fibroblasts produced 5 times higher VEGF than on pure PDLLA films. After 8 weeks of implantation, m-BG and n-BG containing scaffolds were well-infiltrated with newly formed tissue and demonstrated higher vascularisation and percentage blood vessel to tissue 11.6–15.1 than PDLLA scaffolds 8.5. This work thus shows potential for the regeneration of hard-soft tissue defects and increased bone formation arising from enhanced vascularisation of the construct.